75573-22-7

Upstream product

• 119-65-3 isoquinoline 
• 619-41-0 4-(bromoacetyl)toluene 

Downstream Products

• 75573-10-3 2,6‐bis(4‐methylphenyl)‐4‐methoxyphenylpyridine 
• 16112-42-8 2,4,6?tri?p?tolylpyridine 
• 78121-85-4 2-(4-Chloro-phenyl)-4-(4-methoxy-phenyl)-6-p-tolyl-pyridine 
• 72666-42-3 4-(3,4-Dimethoxy-phenyl)-2-phenyl-6-p-tolyl-pyridine 
• 61001-04-5 2-(4-methylphenyl)imidazo[2,1-a]isoquinoline 
• 80242-18-8 3-(4-Methyl-benzoyl)-pyrrolo[2,1-a]isoquinoline-1,2-dicarboxylic acid dimethyl ester 
• 84801-90-1 3-(4-Methyl-benzoyl)-pyrrolo[2,1-a]isoquinoline-1,2-dicarboxylic acid diethyl ester 
• 16112-41-7 4-phenyl-2,6-di(p-tolyl)pyridine 
• 80242-19-9 3-(4-Methyl-benzoyl)-pyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester 
• 61001-19-2 2-(p-tolyl)-5,6-dihydroimidazo[2,1-a]isoquinoline 
• 1227796-88-4 (4-methylphenyl)(pyrrolo[2,1-a]isoquinolin-3-yl)methanone 
• 853319-33-2 diisopropyl 3-(4-methylbenzoyl)pyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate 

Relevant academic research and scientific papers

Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.

Regio- And Stereoselectivity in the 1,3-Dipolar Cycloaddition Reactions of Isoquinolinium Ylides with Cyclopenta[ a ]acenaphthylen-8-ones

A convenient regio- and diastereoselective synthesis of functionalized 5a,5b-dihydro-5 H,13 H -naphtho[1′′,8′′:4′,5′,6′]pentaleno[1′:3,4]pyrrolo[2,1- a ]isoquinolin-5-ones via 1,3-dipolar cycloaddition reaction of 8 H -cyclopenta[a]acenaphthylen-8-ones wi

One-pot synthesis of pyrrolo[2,1-a]isoquinolines via tandem reactions of vinylselenonium salt, 2-bromoethanones, and isoquinoline

An convenient and one-pot synthesis of pyrrolo[2,1-a]isoquinolines via the tandem reaction of methyl(phenyl)vinylselenonium salt with isoquinoline and 2-bromoethanones has been developed, which features very mild conditions, available substrates, simple experimental procedures, moderate to good yields, and wide functional group tolerance.

Studies on Benzopyridinium Ylids: Synthesis of Substituted 2,4,6-Triarylpyridines via Isoquinolinium Ylids

Aroylmethylene-isoquinolinium ylids (1) on reaction with substituted benzylideneacetophenones (2) in gl.acetic acid containing ammonium acetate afford 2,4,6-triarylpyridines (4).The reaction seems to proceed via N-(1,5-dioxo-2-pentyl)-isoquinolium derivat