16112-41-7

Basic information

• Product Name: Pyridine, 2,6-bis(4-methylphenyl)-4-phenyl-
• CAS NO: 16112-41-7
• Molecular Formula: C25H21N
• Molecular Weight: 335.448
• Mol File: 16112-41-7.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: Pyridine, 2,6-bis(4-methylphenyl)-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2,6-bis(4-methylphenyl)-4-phenyl-(16112-41-7)
• EPA Substance Registry System: Pyridine, 2,6-bis(4-methylphenyl)-4-phenyl-(16112-41-7)

Safety Data

• Hazardous Substances Data: 16112-41-7(Hazardous Substances Data)

Upstream product

• 75573-22-7 N-(p-Methylphenacyl)-isoquinoliniumbromide 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 200553-23-7 1-(4-methylphenyl)-2-pyrrolidin-1-ylethanone 
• 14802-30-3 (E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one 
• 100-46-9 benzylamine 
• 766-97-2 4-n-methylphenylacetylene 
• 5720-05-8 4-methylphenylboronic acid 
• 100-52-7 benzaldehyde 
• 75-05-8 acetonitrile 
• 780-25-6 N-benzylidene benzylamine 
• 122-00-9 para-methylacetophenone 
• 96475-75-1 4‐methylacetophenone oxime acetate 
• 53215-95-5 N-(trimethylsilylmethyl)benzylamine 
• 103-67-3 benzyl-methyl-amine 

Downstream Products

• 42178-86-9 4,4'-(4-phenylpyridine-2,6-diyl)dibenzoic acid 
• 1450832-53-7 cis-4-phenyl-2,6-di-p-tolylpiperidine 

Relevant articles and documents

A new route to triphenylpyridines utilizing ketoximes as building blocks via cascade reactions under iron-organic framework catalysis

Iron-based metal–organic framework VNU-20 was utilized as a heterogeneous catalyst for cascade reactions between ketoximes and dibenzyl ether to produce 2,4,6-triphenylpyridines. Additionally, benzyl alcohol and (dimethoxymethyl)benzene could be used as an alternative starting materials for the transformation. The oxidant exhibited a remarkable impact on the reactions, and di-tert-butylperoxide was the most appropriate candidate. The VNU-20 displayed higher efficiency than many homogeneous and heterogeneous catalysts. The catalyst was reusable for the cascade reactions without a noticeable deterioration in catalytic activity. This transformation is new, and would offer alternative routes to triphenylpyridines utilizing ketoximes as building blocks.

TMSOTf-mediated Kr?hnke pyridine synthesis using HMDS as the nitrogen source under microwave irradiation

An efficient protocol for the preparation of pyridine skeletons has been successfully developed involving the TMSOTf/HMDS (trifluoromethanesulfonic acid/hexamethyldisilane) system for the intermolecular cyclization of chalcones under MW (microwave) irradiation conditions. This method provides a facile approach to synthesize 2,4,6-triaryl or 3-benzyl-2,4,6-triarylpyridines in good to excellent yields. Interestingly, the 2,6-diazabicyclo[2.2.2]oct-2-ene core was obtained by changing the acid additive to Sn(OTf)2, and the desired product was also confirmed using X-ray single-crystal diffraction analysis.

Synthesis of Kr?hnke pyridines through iron-catalyzed oxidative condensation/double alkynylation/amination cascade strategy

An efficient protocol for the synthesis of symmetrical and unsymmetrical 2,4,6-trisubstituted pyridines via oxidative cascade annulation of arylacetylenes with benzylamines has been developed. The reaction proceeds smoothly utilizing iron(II) triflate as a catalyst and molecular oxygen as an oxidant with broad substrate scope. Mechanistic studies reveal that the reaction may be experiences an oxidative condensation followed by double alkynylation and amination process.

Copper-catalyzed efficient access to 2,4,6-triphenyl pyridinesviaoxidative decarboxylative coupling of aryl acetic acids with oxime acetates

An efficient and concise approach for the synthesis of 2,4,6-triphenyl pyridines has been developed through copper-catalysed oxidative decarboxylative coupling of C(sp3) aryl acetic acids with oxime acetates in DMF at 150 °C under an oxygen atm