75580-04-0

Basic information

• Product Name: 2-methyl-5-phenoxypyridine
• Synonyms: 2-methyl-5-phenoxypyridine
• CAS NO: 75580-04-0
• Molecular Weight: 185.225
• Mol File: 75580-04-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-methyl-5-phenoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-phenoxypyridine(75580-04-0)
• EPA Substance Registry System: 2-methyl-5-phenoxypyridine(75580-04-0)

Safety Data

• Hazardous Substances Data: 75580-04-0(Hazardous Substances Data)

Upstream product

• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 603-33-8 triphenylbismuthane 
• 3430-13-5 5-bromo-2-methylpyridine 
• 108-95-2 phenol 
• 591-50-4 iodobenzene 
• 2176-45-6 3-phenoxypyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 112945-85-4 2-methyl-5-phenoxypyridine N-oxide 
• 1436378-75-4 N-[(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl]-5-phenoxypyridine-2-carboxamide 
• 936344-43-3 (5-phenoxypyridin-2-yl)methanol 
• 444919-20-4 5-phenoxypyridine-2-carboxylic acid 

Relevant articles and documents

1-substituted 4-arylpiperazine as kappa opioid receptor antagonists

Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.

Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2- methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists

There is continuing interest in the discovery and development of new κ opioid receptor antagonists. We recently reported that N-substituted 3-methyl-4-(3-hydroxyphenyl)piperazines were a new class of opioid receptor antagonists. In this study, we report the syntheses of two piperazine JDTic-like analogues. Evaluation of the two compounds in an in vitro [35S] GTPγS binding assay showed that neither compound showed the high potency and κ opioid receptor selectivity of JDTic. A library of compounds using the core scaffold 21 was synthesized and tested for their ability to inhibit [35S]GTPγS binding stimulated by the selective κ opioid agonist U69,593. These studies led to N-[(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3- methylpiperazin-1-yl]methyl}-2-methylpropyl]-4-phenoxybenzamide (11a), a compound that showed good κ opioid receptor antagonist properties. An SAR study based on 11a provided 28 novel analogues. Evaluation of these 28 compounds in the [35S]GTPγS binding assay showed that several of the analogues were potent and selective κ opioid receptor antagonists.

A new biarylphosphine ligand for the Pd-catalyzed synthesis of diaryl ethers under mild conditions

A new bulky biarylphosphine ligand (L8) has been developed that allows the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions than previously possible. A direct correlation between the size of the ligand substituents in the 2′, 4′, and 6′ positions of the nonphosphine containing ring and the reactivity of the derived catalyst system was observed. Specifically, the rate of coupling increased with the size of these substituents.