7559-47-9

Usage

Uses

Used in Biochemical Research:
Hexadecyl Methanethiosulfonate is used as a reagent for probing the structures of important biological channels and receptors, such as the ACh receptor channel, the GABA receptor channel, and lactose permease. Its specific and rapid reaction with thiols allows researchers to study the function and mechanisms of these channels and receptors in detail.
Used in Pharmaceutical Industry:
Hexadecyl Methanethiosulfonate is used as a tool in drug discovery and development for targeting specific thiol-containing proteins and enzymes. Its ability to form mixed disulfides with thiols can help in the design and optimization of drugs that modulate the activity of these proteins and enzymes, leading to potential therapeutic applications.
Used in Analytical Chemistry:
Hexadecyl Methanethiosulfonate is used as an analytical reagent for the detection and quantification of thiols in various samples. Its specific reaction with thiols allows for selective and sensitive analysis of these compounds, which can be important in various fields such as environmental monitoring, food analysis, and clinical diagnostics.

InChI:InChI=1/C17H36O2S2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-21(2,18)19/h3-17H2,1-2H3

Upstream product

• 6340-98-3 potassium methanethiosulphonate 
• 112-82-3 hexadecanyl bromide 
• 20277-69-4 sodium methansulfinate 

Relevant academic research and scientific papers

Influence of end groups on the stimulus-responsive behavior of poly[oligo(ethylene glycol) methacrylate] in water

The influence of the chemical structure of both end groups onto the lower critical solution temperature (LCST) of poly[oligo(ethylene glycol) monomethyl ether methacrylate] (POEGMA) in water was systematically investigated. POEGMA of Mn = 3550 g/mol and Mw/Mn = 1.14 prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization was equipped with two different functional end groups in a one-step postpolymerization reaction combining activated esters, functional amines, and functional methane thiosulfonates. As end groups, n-propyl, n-hexadecyl, di(n-octadecyl), poly(ethylene glycol)-550 (PEG), 1H,1H-perfluorononyl, azobenzene, and trimethylethylammonium groups were systematically combined with methyl, n-hexadecyl, and 1H,1H,2H,2H-perfluorooctyl groups. Polymers were characterized by gel permeation chromatography, dynamic light scattering, and turbidimetry. Hydrophobic end groups at either end of the polymer chain decreased the LCST. For hydrophobic groups at both ends of the chain their influence was additive. Two large hydrophobic end groups allowed micelle formation below the LCST and an LCST higher than to be expected from nonaggregated polymers. The strongest hydrophobic effect was found for rigid aromatic end groups, which was attributed to their incompatibility with the flexible polymer chain. Charged end groups increased the LCST and could compensate for the effect of hydrophobic end groups at the opposite end group. PEG end groups could mask a hydrophobic influence of the opposite end group and stabilized the LCST.