75591-24-1

Upstream product

• 841-77-0 diphenylmethylpiperazine 
• 60-29-7 diethyl ether 
• 106-89-8 epichlorohydrin 

Downstream Products

• 111452-72-3 1-(diphenylmethyl)-4-(2,3-epoxypropyl)piperazine 
• 125345-79-1 1-(1,2-Epoxy-3-propanyl)-4-[1-(diphenylmethylpiperazin-4-yl]-2-hydroxy-3-propanylthio]-1H-pyrazolo[3,4-d]pyrimidine 
• 129716-70-7 5-[3-(4-Diphenylmethylpiperazine-1-yl)-2-hydroxypropylamino]-8-methoxyquinoline 

Relevant academic research and scientific papers

Synthesis and pharmacological properties of new derivatives of 4-alkoxy-6-methyl-1h-pyrrolo[3,4-c]pyridine- 1,3(2h)-diones

Synthesis of 2-(2-hydroxy-3-amino)propyl derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones (24-35) is described. The chlorides used in the above synthesis exist mainly in the cyclic forms (18, 20-23). Only chloride with benzhydryl

Al(OTf)3-mediated epoxide ring-opening reactions: Toward piperazine-derived physiologically active products

(Chemical Equation Presented) Al(OTf)3 is a good catalyst for the ring opening of epoxides, forming β-amino alcohols bearing the piperazine motif. Two different strategies were examined, where the glycidyl ether resided on one-half of the molec

6-substituted purinyl piperazine derivatives

Novel 6-substituted purinyl piperazine derivatives are described. The novel derivatives are useful as cardiotonic agents and antiarrhythmic agents.

6-substituted purinyl piperazine derivatives

6-substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.

Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes

A series of purine derivatives was prepared and examined for selective inotropic activity in vitro and in vivo. Thioether-linked derivatives were superior to their oxygen and nitrogen isosteres. Substitution of electron- withdrawing groups on the benzhydryl moiety of these agents increased potency. The best compound of the study, 17 (carsatrin), was examined further and demonstrated selective oral activity as a positive inotrope. These compounds are presumed to act by affecting the kinetics of the cardiac sodium channel by analogy to the prototypic agent DPI 201106 (1). Their high selectivity for increasing contractile force and dP/dt without affecting blood pressure or heart rate is consistent with this mechanism. Carsatrin (17) was selected as a potential development candidate.

4-substituted pyrazolo[3,4-d]pyrimidine derivatives

4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarrhythmic agents.

6-substituted purinyl piperazine derivatives

6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.

6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents

6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.

4-Substituted pyrazolo[3,4-D]pyrimidine derivatives

4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarryhythmic agents.