75595-30-1

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 1761-61-1 5-bromosalicyclaldehyde 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 173959-43-8 (2E)-1-(5-bromo-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 

Downstream Products

• 75595-42-5 6-Bromo-3-chloro-2-(4-methoxy-phenyl)-chromen-4-one 
• 75595-98-1 (2R,3S)-6-Bromo-3-chloro-2-(4-methoxy-phenyl)-chroman-4-one 
• 75595-39-0 6-Bromo-3,3-dichloro-2-(4-methoxy-phenyl)-chroman-4-one 
• 1313611-87-8 6-bromo-2-(4-methoxyphenyl)-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one 
• 1313611-95-8 ethyl [6-bromo-2-(4-methoxyphenyl)-2'-oxo-2,3-dihydro-3'H-spiro[chromene-4,5'-[1,3]oxazolidin]-3'-yl]acetate 
• 1313611-71-0 6-bromo-4-[(trimethylsilyl)oxy]-2-(4-methoxyphenyl)-3,4-dihydro-2H-chromene-4-carbonitrile 

Relevant academic research and scientific papers

Organocatalytic Approach for Assembling Flavanones via a Cascade 1,4-Conjugate Addition/oxa-Michael Addition between Propargylamines with Water

A DBU-catalyzed one-pot cascade reaction of propargylamines and water for the synthesis of flavanones has been developed. This process proceeds via a sequence of 1,4-conjugate addition of water to alkynyl o-quinone methide (o-AQM), followed by the alkyne-allene isomerization and subsequent intramolecular oxa-Michael addition. This strategy provides a convenient method for accessing a broad range of flavanones in good to excellent yields with good functional-group tolerance, in particular, the reactive halo functional groups.

Piperidine-mediated annulation of 2-acylphenols with 4-nitrobenzaldehyde to 3-benzofuranones

Piperidine - mediated reactions of 2-acylphenols and 4-nitrobenzaldehydes afforded 3-benzofuranones in high yield (82-95%) at reflux temperature in ethanol. The electron density calculation of HOMO-LUMO energy in the chalcone intermediates by DFT showed t

Synthesis and biological evaluation of 2′-oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic acid derivatives as aldose reductase inhibitors

Aldose reductase (ARL2) is the first enzyme in the polyol pathway which catalyzes the NADPH-dependent reduction of glucose to sorbitol. Its involvement on diabetic complications makes this enzyme a challenge therapeutic target widely investigated to limit