75599-79-0Relevant academic research and scientific papers
Direct synthesis of cyanohydrin esters from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source
Li, Zheng,Zhao, Zhouxing
, p. 3147 - 3155 (2015)
Abstract A direct synthetic method for cyanohydrin esters from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source and tributylphosphine as a promoter is described. This protocol has advantages of no use of strong toxic cyanating agents, high yield, and simple work-up procedure.
Cyanative self-condensation of aromatic aldehydes promoted by VO(O iPr)3-Lewis base as a cooperative catalyst
Kodama, Koichi,Kawamata, Hiroaki,Takahashi, Naoya,Hirose, Takuji
, p. 9440 - 9446 (2013/01/15)
Self-condensation of aromatic aldehydes with trimethylsilyl cyanide proceeded by the cooperative catalytic effect of VO(OiPr)3 and a Lewis base to give the corresponding O-acylated cyanohydrins. The reaction conversion and selectivity were strongly dependent on the solvent used, the Lewis base, and the presence of oxygen. All the nine kinds of aromatic aldehydes considered herein afforded the O-acylated cyanohydrins with excellent selectivity under an O2 atmosphere.
Alkyl phosphines promoted reductive coupling of acyl cyanides: formation of O-acyl cyanohydrins
Zhang, Wen,Shi, Min
, p. 8715 - 8719 (2007/10/03)
The reductive coupling of acyl cyanides promoted by alkyl phosphines has been discovered. Under mild reaction conditions, the substituted cyanohydrins were obtained in moderate to high yields by using trimethylphosphine or tributylphosphine as a promoter.
