75606-30-3Relevant academic research and scientific papers
Cucurbit[6]uril-Promoted Click Chemistry for Protein Modification
Finbloom, Joel A.,Han, Kenneth,Slack, Clancy C.,Furst, Ariel L.,Francis, Matthew B.
supporting information, p. 9691 - 9697 (2017/07/24)
Azide-alkyne cycloaddition is a powerful reaction for the formation of bioconjugates. When catalyzed by Cu(I) or strain promotion, this cycloaddition is considered to be a click reaction with many applications in chemical biology and materials science. We report a new type of azide-alkyne click chemistry for the synthesis of protein conjugates using cucurbit[6]uril (CB6) supramolecular chemistry. CB6-promoted azide-alkyne cycloaddition has been previously used for the synthesis of rotaxanes but has not been applied to the development of complex bioconjugates. By developing new substrates for CB6 click that do not contain any cross-reactive functional groups and by optimizing reaction conditions, we converted CB6 click chemistry from a rotaxane synthesis tool into a useful bioconjugation technique. Using these new parameters, we synthesized a series of protein conjugates including protein-peptide, protein-DNA, protein-polymer, and protein-drug conjugates. We further demonstrated that CB6 click can be used in conjunction with strain-promoted azide-alkyne cycloaddition to generate distinct bioconjugates in protein mixtures. CB6 click is a promising new reaction for the development of protein conjugates and can be applied toward the synthesis of complex biomaterials for a wide range of applications.
Synthesis and radiopharmacological study of unsaturated derivatives of cysteamine
Mesnard,Miginiac,Fatome,et al.
, p. 247 - 252 (2007/10/02)
Synthesis of many unsaturated compounds derivated from cysteamine has been carried out in the three series : β-aminothioethers, β-aminothiols and thiazolidines. These products are more or less toxic, compared to corresponding saturated derivates. They generally have a higher radioprotective activity. The three most effective have a dose reduction factor equivalent to that of cysteamine, two of them having a lower toxicity.
