75612-73-6Relevant academic research and scientific papers
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
Babkov, Denis A.,Khandazhinskaya, Anastasia L.,Chizhov, Alexander O.,Andrei, Graciela,Snoeck, Robert,Seley-Radtke, Katherine L.,Novikov, Mikhail S.
, p. 7035 - 7044 (2015)
The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.
Copper-Catalyzed Alkoxycarbonylation of Alkyl Iodides for the Synthesis of Aliphatic Esters: Hydrogen Makes the Difference
Geng, Hui-Qing,Wu, Xiao-Feng
supporting information, p. 8062 - 8066 (2021/10/25)
A copper-catalyzed alkoxycarbonylation transformation of unactivated alkyl iodides has been developed. Various alkyl iodides can be converted into the corresponding tert-butyl esters in good yields. NaOtBu acts as both a nucleophile and a base. Moreover, other types of aliphatic esters can also be obtained in moderated yields if extra alcohols are added. Both primary and secondary alkyl alcohols can react successfully.
Twist-bend nematic liquid crystals based on thioether linkage
Arakawa, Yuki,Komatsu, Kenta,Tsuji, Hideto
supporting information, p. 6786 - 6793 (2019/05/10)
We developed twist-bend nematogens based on cyanobiphenyl dimers with thioether or sulfur linkage, as opposed to the commonly used methylene and ether linkages. Based on the smaller bond angle of thioether C-S-C than methylene C-CH2-C and ether
Star-shaped trinuclear cyclometalated platinum(II) complexes as single-component emitters in white-emitting PLEDs
Shi, Danyan,Wang, Yafei,Liu, Yu,Zhang, Zhiyong,Luo, Jian,He, Juan,Chen, Qing,Lei, Gangtie,Zhu, Weiguo
supporting information, p. 2096 - 2101 (2012/10/29)
Two star-shaped phosphorescent small molecules, Ph-3FPt(pic) and 4Ph-3FPt(pic), are single-component emitters in polymer white-light-emitting diodes (WPLEDs) that are comprised of three blue-light-emitting phosphorescent chromophores of FPt(pic) and are a
Synthesis and optoelectronic properties of a carbazole-modified platinum(ii) complex in polymer light-emitting devices
Luo, Jian,Liu, Yu,Shi, Danyan,Wang, Yafei,Zhang, Zhiyong,Yu, Junting,Lei, Gangtie,Chen, Qing,Li, Jianmin,Deng, Xianping,Zhu, Weiguo
scheme or table, p. 1074 - 1081 (2012/03/22)
To improve opto-electronic properties and efficiently suppress excimer emission, a phenylpyridine (ppy)-based platinum(ii) complex (C 16OCz-ppy)Pt(acac) was synthesized and characterized, where C 16OCz-ppy is a 2-phenylpyridine deriv
Cyclic hexapeptides having antibiotic activity
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, (2008/06/13)
This invention relates to new polypeptide compound represented by general formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
