75614-75-4Relevant academic research and scientific papers
Site-Selective Functionalization of 7-Azaindoles via Carbene Transfer and Isolation of N-Aromatic Zwitterions
Chen, Qun,Liu, Junheng,Sun, Jiangtao,Tang, Shengbiao,Xu, Guangyang
, p. 9376 - 9380 (2020)
The first systematic study on metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization-aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters.
Ruthenium-catalyzed chemoselective N?H bond insertion reactions of 2-pyridones/7-azaindoles with sulfoxonium ylides
Liu, Xiaofeng,Shao, Ying,Sun, Jiangtao
supporting information, p. 1038 - 1043 (2021/02/06)
A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones has been developed, affording N-alkylated 2-pyridone derivatives in good yields and excellent N-selectivity. The key to achieve this unprecedented N?H rather than O?H insertion reaction is the use of CpRu(PPh3)2Cl as the catalyst and sulfoxonium ylides as the alkylation reagents. Moreover, this protocol is also amenable to 7-azaindoles by slightly varying the reaction conditions. Furthermore, sulfonium ylides are also suitable alkylation reagents, providing the N-alkylated 2-pyridones in good selectivity.
