75614-93-6 Usage
Uses
(S)-(+)-alpha-Methylhistamine Dihydrobromide is an H3 receptor agonist.
Biological Activity
Less active enantiomer of H 3 agonist R-(-)- α -methylhistamine ((R)-(-)-a-Methyl-1H-imidazole-4-ethanaminedihydrobromide ); 120-fold less potent than R-(-) at H 3 .
Check Digit Verification of cas no
The CAS Registry Mumber 75614-93-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,6,1 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 75614-93:
(7*7)+(6*5)+(5*6)+(4*1)+(3*4)+(2*9)+(1*3)=146
146 % 10 = 6
So 75614-93-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H11N3.2BrH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m0../s1
75614-93-6Relevant articles and documents
Histamine analogues. 32nd communication: synthesis and pharmacology of sopromidine, a potent and stereoselective isomer of the achiral H2-agonist impromidine
Elz, Sigurd,Gerhard, Guenter,Schunack, Walter
, p. 259 - 262 (2007/10/02)
Synthesis and pharmacology of sopromidine ((R)-7) and (S)-7, 2 position isomers of impromidine derived from the enantiomeric α-methylhistamines, are reported.The enantiomers of 7 show high stereoselectivity at the atrial H2-receptor of the guinea-pig. (R)-7 is revealed to be a full H2-agonist with 7.4-fold potency relative to histamine, while (S)-7 is a competitive H2-antagonist. chiral H2-agonists / histamine H2-receptor / impromidine analogues / α-methylhistamine
