75626-18-5

Usage

Physical state

Colorless liquid

Odor

Faint aromatic

Uses

a. Production of pharmaceuticals
b. Synthesis of other organic compounds
c. Solvent in various chemical reactions

Stability

High

Reactivity

Low

Safety

Handle with care due to potential health hazards

Upstream product

• 75626-23-2 3,6-Difluorocatechol 
• 77-78-1 dimethyl sulfate 
• 75626-22-1 3,6-difluoro-2-hydroxyanisole 
• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 72912-50-6 5,8-difluoro-2,3-dihydro-1,4-benzodioxin 
• 75626-17-4 2,5-difluoroanisole 
• 72912-49-3 2-(2,3,6-trifluorophenoxy)ethanol 
• 2713-31-7 2,5-difluorophenol 
• 540-36-3 para-difluorobenzene 
• 186581-53-3 diazomethane 

Downstream Products

• 75626-19-6 1-Chloromethyl-2,5-difluoro-3,4-dimethoxy-benzene 
• 127685-84-1 3,6-Difluoro-4-methyl-5-nitro-benzene-1,2-diol 
• 127685-83-0 1,4-difluoro-2,3-dimethoxy-5-methyl-6-nitrobenzene 
• 127685-87-4 4,7-difluoro-5,6-<(diphenylmethylene)dioxy>indole 
• 127685-85-2 1,4-difluoro-2,3-<(diphenylmethylene)dioxy>-5-methyl-6-nitrobenzene 
• 127685-89-6 5,6-<(diphenylmethylene)dioxy>-4-fluoro-7-piperidinoindole 
• 127685-86-3 [(E)-2-(4,7-Difluoro-6-nitro-2,2-diphenyl-benzo[1,3]dioxol-5-yl)-vinyl]-dimethyl-amine 
• 127685-88-5 1,2-<(diphenylmethylene)dioxy>-3-fluoro-4-methyl-5-nitro-6-piperidinobenzene 
• 75626-15-2 <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine 
• 75626-16-3 <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine hydrobromide 
• 75626-20-9 (2,5-Difluoro-3,4-dimethoxy-phenyl)-acetonitrile 
• 127685-82-9 1,4-difluoro-2,3-dimethoxy-5-methylbenzene 

Relevant academic research and scientific papers

Synthesis of novel tetrahydroisoquinoline bronchodilators

The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly

Transformation of difluorinated phenols by Penicillium frequentans Bi 7/2

The Penicillium frequentans strain Bi 7/2, using phenol as a sole source of carbon and energy, transformed the fluorinated phenols 2,3-, 2,4-, 2,5- and 3,4-difluorophenol rapidly. After growth on phenol, resting mycelia of the fungus converted the difluorophenols completely at an initial concentration of 0.5mM within 6 hours. The corresponding difluorinated catechols were found to be intermediates of all difluorophenols investigated. A relatively unspecific phenol hydroxylase catalyzed this hydroxylation step and showed activities towards all difluorophenols tested. One difluorocatechol was formed from each difluorophenol substituted with fluorine in the ortho-position, whereas two catechols were formed from 3,4-difluorophenol, due to its two vacant ortho-positions. A partial defluorination (50-77%) was observed in all cases.