756422-90-9Relevant academic research and scientific papers
A biocatalytic cascade for the amination of unfunctionalised cycloalkanes
Tavanti, Michele,Mangas-Sanchez, Juan,Montgomery, Sarah L.,Thompson, Matthew P.,Turner, Nicholas J.
, p. 9790 - 9793 (2017)
Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space-time yield of 2 g L-1 d-1.
