75643-44-6

Usage

InChI:InChI=1/C17H9Cl2N3O/c18-13-7-3-1-5-10(13)15-12(9-20)17(23)22-21-16(15)11-6-2-4-8-14(11)19/h1-8H,(H,22,23)

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 21854-95-5 2,2'-dichlorobenzil 
• 75644-22-3 2,2'-dichloro-benzil-monohydrazone 

Downstream Products

• 75660-48-9 5,6-Bis-(2-chloro-phenyl)-2-(2-hydroxy-ethyl)-3-oxo-2,3-dihydro-pyridazine-4-carbonitrile 

Relevant academic research and scientific papers

CCSO nano catalyzed solid phase synthesis of 3-oxo-5,6-disubstituted-2,3-dihydropyridazine-4-carbonitrile

Co-doped Ce0.94Ca0.05Sr0.01O1.94 (CCSO) nano particles have been successfully synthesized by an auto-combustion method and were characterized by XRD, TEM and AFM analyses. The catalytic activity of the nano-catalyst is evaluated by the synthesis of substituted pyridazines from substituted benzil and cyano acetylhydrazide, which have great biological and pharmaceutical interest. Thus, a highly economically efficient one-pot solvent free synthesis of pyridazine was developed, which is promoted by the CCSO nano catalyst. The benefits of the reaction are its very short time (2-4 min) and high yields (90-95%). The method offers a highly convergent, inexpensive, and functionality-tolerable procedure for rapid access to important pyridazine compounds in good yields. This journal is

Antihypertensive 5,6-diarylpyridazin-3-ones

The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent co