756458-80-7Relevant academic research and scientific papers
Structure-based design of novel human Pin1 inhibitors (II)
Dong, Liming,Marakovits, Joseph,Hou, Xinjun,Guo, Chuangxing,Greasley, Samantha,Dagostino, Eleanor,Ferre, RoseAnn,Johnson, M. Catherine,Kraynov, Eugenia,Thomson, James,Pathak, Ved,Murray, Brion W.
supporting information; experimental part, p. 2210 - 2214 (2010/06/15)
Following the discovery of a novel series of phosphate-containing small molecular Pin1 inhibitors, the drug design strategy shifted to replacement of the phosphate group with an isostere with potential better pharmaceutical properties. The initial loss in potency of carboxylate analogs was likely due to weaker charge-charge interactions in the putative phosphate binding pocket and was subsequently recovered by structure-based optimization of ligand-protein interactions in the proline binding site, leading to the discovery of a sub-micromolar non-phosphate small molecular Pin1 inhibitor.
Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1)
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Page/Page column 54, (2010/02/14)
Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell proliferation, infectious diseases, and neurodegenerative brain disorders, by administering effective amounts of such compounds.
