756481-32-0

Basic information

• Product Name: 6-amino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-1H-pyrimidine-2,4-dione
• CAS NO: 756481-32-0
• Molecular Weight: 293.753
• Mol File: 756481-32-0.mol

Chemical Properties

• CAS DataBase Reference: 6-amino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-1H-pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-1H-pyrimidine-2,4-dione(756481-32-0)
• EPA Substance Registry System: 6-amino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-1H-pyrimidine-2,4-dione(756481-32-0)

Safety Data

• Hazardous Substances Data: 756481-32-0(Hazardous Substances Data)

Upstream product

• 34123-57-4 3-[4-(1-methylethyl)phenyl]-1-methylurea 
• 31027-31-3 4-isopropylphenylisocyanate 
• 372-09-8 cyanoacetic acid 
• 756481-34-2 1-(2-chloro-4-isopropyl-phenyl)-3-methyl-urea 

Downstream Products

• 756481-46-6 7-benzyloxymethyl-3-(2-chloro-4-isopropylphenyl)-8-ethyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione 
• 756481-47-7 1-benzyloxymethyl-4-[(2-chloro-4-isopropylphenyl)amino]-2-ethyl-N-methyl-1H-imidazole-5-carboxamide 
• 756481-48-8 7-benzyloxymethyl-3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one 
• 756481-20-6 3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 756481-49-9 3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one 
• 756481-24-0 5,6-diamino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 1027973-23-4 6-amino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-5-nitroso-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Design, synthesis, and biological evaluation of 1,2,3,7-tetrahydro-6H- purin-6-one and 3,7-dihydro-1H-purine-2,6-dione derivatives as corticotropin-releasing factor1 receptor antagonists

A growing body of evidence suggests that CRF1 receptor antagonism offers considerable therapeutic potential in the treatment of diseases resulting from elevated levels of CRF, such as anxiety and depression. A series of novel 1,2,3,7-tetrahydro-6H-purin-6-one and 3,7-dihydro-1H-purine-2, 6-dione derivatives was synthesized and evaluated as corticotropin releasing factor-1 (CRF1) receptor antagonists. Compounds within this series, represented by compound 12d (IC50 = 5.4 nM), were found to be highly potent CRF1 receptor antagonists. In addition, compounds 12d and 12j were determined to be selective CRF1 antagonists. The synthesis, structure-activity relationships and pharmacokinetic properties of compounds within this series is presented.