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CAS

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756481-48-8

7-benzyloxymethyl-3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 756481-48-8 Structure

  • Basic information

    1. Product Name: 7-benzyloxymethyl-3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one
    2. Synonyms:
    3. CAS NO:756481-48-8
    4. Molecular Formula:
    5. Molecular Weight: 452.984
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 756481-48-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 7-benzyloxymethyl-3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 7-benzyloxymethyl-3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one(756481-48-8)
    11. EPA Substance Registry System: 7-benzyloxymethyl-3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one(756481-48-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 756481-48-8(Hazardous Substances Data)

756481-48-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 756481-48-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,6,4,8 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 756481-48:
(8*7)+(7*5)+(6*6)+(5*4)+(4*8)+(3*1)+(2*4)+(1*8)=198
198 % 10 = 8
So 756481-48-8 is a valid CAS Registry Number.

756481-48-8Downstream Products

756481-48-8Relevant articles and documents

Design, synthesis, and biological evaluation of 1,2,3,7-tetrahydro-6H- purin-6-one and 3,7-dihydro-1H-purine-2,6-dione derivatives as corticotropin-releasing factor1 receptor antagonists

Hartz, Richard A.,Nanda, Kausik K.,Ingalls, Charles L.,Ahuja, Vijay T.,Molski, Thaddeus F.,Zhang, Ge,Wong, Harvey,Peng, Yong,Kelley, Michelle,Lodge, Nicholas J.,Zaczek, Robert,Gilligan, Paul J.,Trainor, George L.

, p. 4741 - 4754 (2007/10/03)

A growing body of evidence suggests that CRF1 receptor antagonism offers considerable therapeutic potential in the treatment of diseases resulting from elevated levels of CRF, such as anxiety and depression. A series of novel 1,2,3,7-tetrahydro-6H-purin-6-one and 3,7-dihydro-1H-purine-2, 6-dione derivatives was synthesized and evaluated as corticotropin releasing factor-1 (CRF1) receptor antagonists. Compounds within this series, represented by compound 12d (IC50 = 5.4 nM), were found to be highly potent CRF1 receptor antagonists. In addition, compounds 12d and 12j were determined to be selective CRF1 antagonists. The synthesis, structure-activity relationships and pharmacokinetic properties of compounds within this series is presented.

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