756482-12-9Relevant academic research and scientific papers
Preparations and spectroscopic studies of organotin complexes of diclofenac
Kourkoumelis, Nikolaos,Demertzis, Mavroudis A.,Kovala-Demertzi, Dimitra,Koutsodimou, Aglaia,Moukarika, Alice
, p. 2253 - 2259 (2004)
The reactions of the potent and widely used anti-inflammatory drug diclofenac, HL, with diorganotin(IV) oxides were studied. The dimeric tetraorganodistannoxane complexes [Me2LSnOSnLMe2] 2, [Bu2LSnOSnLBu2]2, [Ph 2LSnOSnLPh2]2 and the dibutyltin complex [Bu2SnL2], have been prepared and structurally characterized in the solid state by means of vibrational and 119Sn M?ssbauer spectroscopy. Determination of lattice dynamics by temperature-dependent 119Sn M?ssbauer spectroscopy. From the variable-temperature M?ssbauer effect, the Debye temperature was determined. The complexes have been characterized in solution by NMR ( 1H and 13C) spectroscopy. Vibrational, M?ssbauer, and NMR data are discussed in terms of the proposed structures.
