2273-45-2Relevant academic research and scientific papers
The structure of 2,2-di-t-butyl-1,3,2-dioxa-, oxathia-, and dithia-stannolanes: a study by solution and solid state NMR and single crystal X-ray diffraction
Bates, Paul A.,Hursthouse, Michael B.,Davies, Alwyn G.,Slater, Sean D.
, p. 45 - 60 (1989)
X-Ray diffraction shows that 2,2-di-t-butyl-1,3,2-dioxastannolane exists as a 5-coordinate dimer.The corresponding oxathiastannolane is similarly dimerised through oxygen, but in the crystalline phase the dithiastannolane is a 4-coordinate monomer.Comparison of the 117/119Sn NMR spectra of the compounds as solids and in solution shows that in solution, the dioxastannolane retains its dimeric structure, but the dimeric oxathiastannolane is in equilibrium with the monomer, and the dithiastannolane is a simple monomer.
Structural investigations on diorgano- and triorganotin(IV) derivatives of [meso-tetra(4-sulfonatophenyl)porphine] metal chlorides
Pellerito,Scopelliti,Fiore,Nagy,Barone,Abbate,Stocco,Pellerito
, p. 1573 - 1583 (2006)
Several new complexes of organotin(IV) moieties with MCl n[meso-tetra(4-sulfonatophenyl)porphine], (R2Sn) 2MCln[meso-tetra(4-sulfonatophenyl)-porphinate]s and (R3Sn)4MCln [meso-tetra(4-sulfonatophenyl) porphinate]s, [M = Fe(III), Mn(III): n = 1, R = Me, n-Bu; Ph; M = Sn(IV): n = 2, R = Me, n-Bu] have been synthesized and their solid state configuration investigated by infrared (IR) and M?ssbauer spectroscopy, and by 1H and 13C NMR in D2O. The electron density on the metal ion coordinated inside the porphyrin ring is not influenced by the organotin(IV) moieties bonded to the oxygen atoms of the side chain sulfonatophenyl groups, as it has been inferred on the basis of M?ssbauer spectroscopy and, in particular, from the invariance of the isomer shift of the Fe(III) and Sn(IV) atoms coordinated into the porphyrin square plane of the newly synthesized complexes, with respect to the same atoms in the free ligand. As far as the coordination polyhedra around the peripheral tin atoms are concerned, infrared spectra and experimental M?ssbauer data would suggest octahedral and trigonal bipyramidal environments around tin, in polymeric configurations obtained, respectively, in the diorganotin derivatives through chelating or bridging sulfonate groups coordinating in the square plane, and in triorganotin(IV) complexes through bridging sulfonate oxygen atoms in axial positions. The structures of the (Me3Sn)4Sn(IV)Cl 2[meso-tetra(4-sulfonatophenyl)porphinate] and of the two model systems, Me3Sn(PS)(HPS) and Me2Sn(PS)2 [HPS = phenylsulfonic acid], have been studied by a two layer ONIOM method, using the hybrid DFT B3LYP functional for the higher layer, including the significant tin environment. This approach allowed us to support the structural hypotheses inferred by the IR and M?ssbauer spectroscopy analysis and to obtain detailed geometrical information of the tin environment in the compounds investigated. 1H and 13C NMR data suggested retention of the geometry around the tin(IV) atom in D2O solution.
Polymeric seven-coordinated organotin(IV) complexes derived from 5-amino-2-chlorobenzoic acid and in vitro anti-cancer studies
Win, Yip-Foo,Choong, Chen-Shang,Dang, Jia-Chin,Iqbal, Muhammad Adnan,Quah, Ching Kheng,Majid, Amin Malik Shaw Abdul,Teoh, Siang-Guan
, p. 3401 - 3413 (2014)
Cancer cases are alarmingly increasing worldwide, and newer chemotherapeutic agents are needed. Recent analogs of cisplatin (carboplatin, lobaplatin, nedaplatin and oxaliplatin) and their marketing as advanced chemotherapeutic drugs have furthered the interest in metal-based anti-cancer drugs. In the current study, two new polymeric organotin(IV) carboxylate complexes (1 and 2) have been synthesized and characterized. Spectroscopic studies showed that coordination took place via carboxylates. Furthermore, X-ray crystallographic study on 1 indicated that it possesses a monomeric structure and exists in polymeric formation due to additional Sn-N coordination, assigning seven coordinations to each metal ion. Both the complexes were tested against three cancerous (human colon cancer, HCT 116; breast cancer, MCF-7; and leukemia, K562) and one non-cancerous (3T3-L1) cell lines. Complex 1 showed exceptional cytotoxicity against cancerous cell lines (IC50 = 1.0 M for HCT 116; 258.7 nM for MCF-7; and 46.7 nM K562) and remained comparatively non-toxic against normal cells (IC50 = 37.0 M). This shows that both complexes have selective cytotoxicity against cancer cells.
The crystal structure of dichlorobis(imidazole)dimethyltin(IV)
Martinez, E. Garcia,Gonzalez, A. Sanchez,Macias, A.,Castano, M.V.,Casas, J.S.,Sordo, J.
, p. 329 - 334 (1990)
The structure of dichlorobis(imidazole)dimethyltin(IV) has been determined by X-ray diffraction.The crystal consists of discrete trans-Me2SnCl2(HIm)2 units with the metal atom octahedrally coordinated to two Cl atoms (Sn-Cl, 2.5955(7) Angstroem; Cl-Sn-Cl,
Synthesis, characterization, thermal, and antibacterial studies of organotin(Iv) complexes of indole-3-butyric acid and indole-3-propionic acid
Chilwal, Asha,Malhotra, Priti,Narula
, p. 410 - 421 (2014/03/21)
Six organotin(IV) complexes of type Me2SnL2, Bu 2SnL2, and Ph3SnL [where L = indole-3-butyric acid (1, 2 and 3) or indole-3-propionic acid (4, 5 and 6)] have been synthesized by the reactions of the corresponding diorganotin(IV) oxide and triphenyltin(IV) hydroxide with respective indole-3-butyric acid (IBH) or indole-3-propionic acid (IPH) in the desired molar ratios of 1:2/1:1. All of the compounds have been characterized by elemental analysis, IR, 1H NMR, 13C NMR, and 119Sn NMR spectroscopy. Thermal studies of all synthesized complexes have been carried out using thermogravimetry (TG) technique under a nitrogen atmosphere. The thermal decompositions for compounds Me2SnL2 and Bu2SnL2 occurred in two steps, whereas in compounds Ph3SnL, it exhibited as three steps decomposition and resulted into the formation of pure SnO2. The complexes were also screened against three gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, and Micrococcus luteus) and three gram-negative (Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes) bacteria using minimum inhibition concentration (MIC) method, and all of these complexes showed significant antibacterial activity. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental files: Additional text, tables, and figures.]
Synthesis, characterization and antibacterial activity of organotin(IV) complexes derivatives of 2-chloro-4-nitrobenzoic acid
Choong, Chen-Shang,Win, Yip-Foo,Ha, Sie-Tiong,Yousif, Emad
, p. 2949 - 2953 (2014/06/09)
Four organotin(IV) carboxylate complexes have been successfully synthesized and characterized quantitatively and qualitatively. Spectroscopic studies showed that the coordination took place via oxygen atoms from the carboxylate anions. With the exceptiona
Synthesis, characterization and preliminary in vitro antibacterial screening activity of organotin(IV) complexes derivatives of 2-amino-3-nitrobenzoic acid
Choong, Chen-Shang,Ha, Sie-Tion,Heng, Mei-Hsuan,Win, Yip-Foo
, p. 7235 - 7238 (2015/04/22)
A total of four organotin(IV) carboxylate complexes have been synthesized and characterized quantitatively and qualitatively. Spectroscopy studies indicated that the coordination took place via oxygen atoms from the carboxylate anions. Moreover, all the complexes obtained as simple monomeric structure except complex 3 which was obtained as organodistannoxane dimer types. From the preliminary in vitro antibacterial screening activity, triphenyltin(IV) (complex 4) showed significant activity against Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus and complex 2 only possessed better activity against Pseudomonas aeruginosa.
Preliminary in vitro cytotoxic assay on HepG2 and antibacterial screening activity: Synthesis and characterization of organotin(IV) complexes derivatives of 2-methyl-3-nitrobenzoic acid
Win, Yip-Foo,Teoh, Siang-Guan,Ha, Sie-Tiong,Tengku-Muhammad, Tengku-Sifzizul,Yousif, Emad
, p. 3376 - 3380 (2013/05/09)
Three organotin(IV) carboxylate complexes derivatives of 2-methyl-3-nitrobenzoic acid (HL) have been successfully synthesized and characterized quantitatively and qualitatively. The complexes obtained are screened for their preliminary in vitro cytotoxic
First gas-phase detection of dimethylstannylene and time-resolved study of some of its reactions
Becerra, Rosa,Boganov, Sergey E.,Egorov, Mikhail P.,Faustov, Valery I.,Krylova, Irina V.,Nefedov, Oleg M.,Walsh, Robin
, p. 7555 - 7562 (2007/10/03)
Using a laser flash photolysis/laser probe technique, we report the observation of strong absorption signals in the wavelength region 450-520 nm (highest intensity at 514.5 nm) from four potential precursors of dimethylstannylene, SnMe2, subjected to 193 nm UV pulses. From GC analyses of the gaseous products, combined with quantum chemical excited state CIS and TD calculations, we can attribute these absorptions largely to SnMe2, with SnMe4 as the cleanest source of the species. Kinetic studies have been carried out by time-resolved monitoring of SnMe2. Rate constants have been measured for its reactions with 1,3-C4H6, MeC, CMe, MeOH, 1-C4H9Br, HCl, and SO2. No evidence could be found for reaction of SnMe2 with C2H4, C3H8, Me3SiH, GeH4, Me2GeH2, or N2O. Limits of less than 10-13 cm3 molecule-1 s-1 were set for the rate constants for these latter reactions. These measurements showed that SnMe2 does not insert readily into C-H, Si-H, Ge-H, C-C, Si-C, or Ge-C bonds. It is also unreactive with alkenes although not with dienes or alkynes. It is selectively reactive with lone pair donor molecules. The possible mechanisms of these reactions are discussed. These results represent the first visible absorption spectrum and rate constants for any organo-stannylene in the gas phase.
Synthesis of organotin oxides
-
, (2008/06/13)
Organotin oxides are synthesized by reacting powdered tin metal with an alcohol at elevated temperatures on the order of about 200-400° C. Monoalkyltin, dialkyltin and trialkyltin oxides are produced in quantitative yields according to the method.
