756533-19-4

Upstream product

• 841255-60-5 4-Methoxy-benzoic acid (3S,4R)-4-(4-bromo-phenylsulfanyl)-3-hydroxy-tetrahydro-pyran-3-ylmethyl ester 
• 100-07-2 4-methoxy-benzoyl chloride 
• 756533-15-0 4-methoxy-benzoic acid 5,6-dihydro-2H-pyran-3-ylmethyl ester 
• 756533-16-1 4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester 
• 756533-17-2 4-Methoxy-benzoic acid (3aS,7aS)-2,2-dioxo-dihydro-2λ⁶-[1,3,2]dioxathiolo[4,5-c]pyran-3a-ylmethyl ester 

Downstream Products

• 756533-82-1 (3S,4R)-3-Hydroxy-4-(4'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-carboxylic acid 
• 756533-80-9 (3S,4R)-3-Hydroxy-4-(2'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-carboxylic acid 
• 756533-81-0 (3S,4R)-3-Hydroxy-4-(3'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-carboxylic acid 
• 756533-59-2 (3R,4R)-3-Hydroxymethyl-4-(4'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-ol 
• 756533-58-1 (3R,4R)-3-Hydroxymethyl-4-(3'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-ol 
• 756533-57-0 (3R,4R)-3-Hydroxymethyl-4-(2'-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-ol 

Relevant academic research and scientific papers

3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase

N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure-activity relationships are reported. N-Hydroxy-3-hydroxy-4- arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure-activity relationships are reported.