75666-67-0

Upstream product

• 75666-59-0 2'-(O-tert-butyldimethylsilyl)-3'-O-levulinoyl-5'-O-(p-methoxyphenyldiphenylmethyl)-N²-benzoylguanosine 
• 70689-36-0 N-(9-{(2R,3R,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide 
• 123-76-2 levulinic acid 

Relevant academic research and scientific papers

Ceric ammonium nitrate on silica gel for efficient and selective removal of trityl and silyl groups

Silicna gel-supported ceric ammonium nitrate (CAN-SiO2) was found effective for rapid and selective cleavage of trityl (Tr), monomethoxytrityl (MMTr), and dimethoxytrityl (DMTr) groups from protected nucleosides and nucleotides under mild conditions. Efficiency of deprotections depended upon the stability of th resultant carbocationic species: DMTr+ > MMTr+ > Tr+. Use of a catalytic amount of this solid-supported reagent can also efficiently and selectively remove the tert butyldimethylsilyl or the triisopropylsilyl group from a primary hydroxyl functionality in di- or trisilyl ethers of ribonucleosides. A comparative stud of deprotection reactions by utilization of CAN alone or CAN-SiO2 indicates a remarkable increase in the rate of the reactions involving a solid support. The mechanism of electron-transfer processes is proposed for the use of CAN-SiO2 in the removal of these protective groups from organic molecules.

The synthesis of oligoribonucleotides VI. The synthesis of a hexadecamer by a block condensation approach

The synthesis of the 5'-monomethoxytrityl-2'-tert-butyldimethylsilyl-3'-levulinylribonucleosides 4 of the four major bases involved in the phosphite procedure for the synthesis of oligoribonucleotides is described along with the 2',3'-isomeric derivatives