756790-25-7Relevant academic research and scientific papers
Discovery of Novel Celastrol Derivatives as Hsp90-Cdc37 Interaction Disruptors with Antitumor Activity
Li, Na,Xu, Manyi,Wang, Bing,Shi, Zhixian,Zhao, Zihao,Tang, Yunqing,Wang, Xinyue,Sun, Jianbo,Chen, Li
, p. 10798 - 10815 (2019)
To develop novel and efficient heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) interaction disruptors, several lipophilic fragments were introduced into celastrol (CEL) to synthesize 48 new CEL derivatives. Among all the target compounds, 41 wa
Design, synthesis and SARs of novel telomerase inhibitors based on BIBR1532
Chen, Fei Hu,Liu, Chao,Liu, Xin Hua,Sheng, Xiao Bao,Zhou, Hua
, (2020/07/21)
Telomerase has become one of the new popular targets for the development of anti-tumor drugs. Based on the structural characteristics of the BIBR1532 which has entered the stage of clinical research, six series total of 64 new compounds with diverse struc
Synthesis of coumarins via PIDA/I2-mediated oxidative cyclization of substituted phenylacrylic acids
Li, Jinming,Chen, Huiyu,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
, p. 4311 - 4320 (2013/04/24)
A variety of functionalized coumarins were synthesized from substituted phenylacrylic acids via PIDA/I2-mediated and irradiation-promoted oxidative carbon-oxygen bond formation. Our studies show that the oxygen in the pendant carboxylic acid group cyclizes favorably to the aryl ring that is cis to it. The main advantages of this method include good functional group tolerance and the transition-metal-free characteristic. The Royal Society of Chemistry 2013.
A short, chemoenzymatic route to chiral β-aryl-γ-amino acids using reductases from anaerobic bacteria
Fryszkowska, Anna,Fisher, Karl,Gardiner, John M.,Stephens, Gill M.
supporting information; experimental part, p. 533 - 535 (2010/05/11)
A short chemoenzymatic synthesis of β-aryl-γ-aminobutyric acids has been developed, based on a highly enantioselective biocatalytic reduction of β-aryl-β-cyano-α,β-unsaturated carboxylic acids.
