Journal of Medicinal Chemistry p. 10798 - 10815 (2019)
Update date:2022-08-15
Topics:
Li, Na
Xu, Manyi
Wang, Bing
Shi, Zhixian
Zhao, Zihao
Tang, Yunqing
Wang, Xinyue
Sun, Jianbo
Chen, Li
To develop novel and efficient heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) interaction disruptors, several lipophilic fragments were introduced into celastrol (CEL) to synthesize 48 new CEL derivatives. Among all the target compounds, 41 wa
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