756819-70-2

Basic information

• Product Name: Acetic acid, [(dimethylamino)methylene]hydrazide (9CI)
• Synonyms: Acetic acid, [(dimethylamino)methylene]hydrazide (9CI)
• CAS NO: 756819-70-2
• Molecular Formula: C5H11N3O
• Molecular Weight: 129.16034
• Product Categories: AMINETERTIARY
• Mol File: 756819-70-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetic acid, [(dimethylamino)methylene]hydrazide (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [(dimethylamino)methylene]hydrazide (9CI)(756819-70-2)
• EPA Substance Registry System: Acetic acid, [(dimethylamino)methylene]hydrazide (9CI)(756819-70-2)

Safety Data

• Hazardous Substances Data: 756819-70-2(Hazardous Substances Data)

Upstream product

• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 1068-57-1 acetic acid hydrazide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Relevant articles and documents

TRIAZOLE DERIVATIVES

The present invention relates to compounds of formula I; wherein R1' is CH3 R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1 and R1 may form together a l,l-dioxo-tetrahydro-thiophen-3-yl ring; R is hydrogen, methyl, ethyl, isopropyl, tert-butyl, cyclopropyl, hydroxmethyl, or 2-propyl- 2-ol; RJ is CI, F, CF3, cyano, methyl, methoxy, isopropyl, or cyclopropyl; R4 is hydrogen, methyl, F or CI; or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds of formula I may be used in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism spectrum disorder. It has been surprisingly been found that the compounds of general formula I are EAAT3 inhibitors. The excitatory amino acid transporter 3 (EAAT3), also referred to in human studies as solute carrier family 1, member 1 (systematic gene name: SLC1A1) and in rodents as excitatory amino acid carrier 1 (EAAC1), is a high-affinity anionic amino acid transporter found in neurons throughout the cortex and in the hippocampus, basal ganglia (striatum, thalamus), and the olfactory bulb. EAAT3 functions to buffer local glutamate concentrations at excitatory synapses,

Microwave-assisted and efficient one-pot synthesis of substituted 1,2,4-triazoles

An efficient microwave-assisted one-pot and three-component synthesis of substituted 1,2,4-triazoles has been achieved utilizing substituted primary amines.

Efficient and regiospecific one-pot synthesis of substituted 1,2,4-triazoles

(Equation Presented) An efficient one-pot, three-component synthesis of substituted 1,2,4-triazoles has been developed, utilizing a wide range of substituted primary amines and acyl hydrazides.