756875-51-1Relevant academic research and scientific papers
Synthesis method of sphingosine kinase agonist
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Paragraph 0006; 0019; 0022-0023; 0024; 0027; 0028; 0031, (2022/01/10)
The invention discloses a synthesis method of a sphingosine kinase agonist K6PC-5, and belongs to the technical field of organic synthesis. The synthesis method comprises the specific steps: (1), taking capryloyl chloride (a compound II) as a raw material, and performing reaction in dichloromethane under the action of triethylamine to obtain an intermediate III; and (2) reacting the intermediate III with serinol to obtain a compound I, namely the agonist K6PC-5. The synthesis method is simple to operate, economical, efficient and applicable to large-scale production, the intermediate III is prevented from being excessively exposed in air after being formed by the aid of a one-pot method, the deterioration possibility of the intermediate III is reduced, and the whole operation is safe, reliable, rapid and efficient.
