75700-33-3Relevant academic research and scientific papers
The Conversion of Secondary into Tertiary Amides Using Benzotriazole Methodology
Katritzky, Alan R.,Yao, Guowei,Lan, Xiangfu,Zhao, Xiaohong
, p. 2086 - 2093 (2007/10/02)
N-Alkyl-N-amides, easily prepared from benzotriazole, an aldehyde, and a secondary amide, react readily with organozinc reagents to give tertiary amides in moderate to good yields.They are also reduced by LiAlH4 to afford tertiary amines.
UREAS IN ORGANIC SYNTHESIS. V. REACTIONS OF AROMATIC KETONES AND 1,2-DIKETONES WITH UREAS IN FORMIC ACID
Bakibaev, A.A.,Yagovkin, A.Yu.,Filimonov, V.D.
, p. 1326 - 1331 (2007/10/02)
Urea in formic acid is a general and practical reagent for the reductive aminoformylation of benzophenones and fluoren-9-one in the synthesis of N-diarylmethylformamides, which exhibit antispasmodic activity.With benzophenone in formic acid 1,3-dimethylurea gives a high yield of N-methyl-N-benzhydrylformamide.Urea reacts selectively with benzil and benzoin, forming both the bicyclic bisurea and monocyclic nitrogen-containing heterocycles, depending on the temperature.It was proposed for the first time to use arylmethylenebisureas as reagents in reaction with benzil for the production of 1,5-diphenyl-2,4,6,8-tetraazabicyclooctane-3,7-dione or 2,4,5-triphenylimidazole.
