75702-09-9Relevant academic research and scientific papers
Analgesic narcotic antagonists. IV. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxymorphinan-6-ones and -isomorphinan-6-ones
Leland,Kotick
, p. 1427 - 1431 (1980)
3,6-Dimethoxy-7β,17-dimethyl-4-hydroxy-5,6,8,14-tetradehydromorphinan (2) was converted to the 4-deoxy compound 4 and hydrolyzed to a mixture of the B/C-cis (C series) and B/C-trans (T series) isomers of 7,8-didehydromorphinan-6-one, 5. Hydrogenation of t
7-Methyl-8β-lower alkyl or 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds and therapeutic method of treating pain employing them
-
, (2008/06/13)
Disclosed are 7-methyl, 8β-lower alkyl and 7 methyl-8-lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: STR1 Specific compounds, included within the scope of the foregoing general formula wherein R1 is H or methyl, R2 is cyclopropylmethyl or cyclobutylmethyl, R3 is H, methyl, ethyl or n-propyl and R4 is H or methyl are useful as mixed analgesics/narcotic antagonists.
