Analgesic narcotic antagonists. IV. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxymorphinan-6-ones and -isomorphinan-6-ones

DOI: 10.1021/jm00186a025

Source and publish data:

Journal of Medicinal Chemistry p. 1427 - 1431 (1980)

Update date:2022-08-02

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Authors:

Leland Leland

Kotick Kotick

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Article abstract of DOI:10.1021/jm00186a025

3,6-Dimethoxy-7β,17-dimethyl-4-hydroxy-5,6,8,14-tetradehydromorphinan (2) was converted to the 4-deoxy compound 4 and hydrolyzed to a mixture of the B/C-cis (C series) and B/C-trans (T series) isomers of 7,8-didehydromorphinan-6-one, 5. Hydrogenation of t

Full text of DOI:10.1021/jm00186a025

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