757172-54-6

Upstream product

• 220903-42-4 (R)-N-tert-butyloxycarbonyl-(3-benzyloxy-2-chloro-4-methoxy)-phenylalanine ethyl ester 
• 210105-84-3 (R)-N-tert-butyloxycarbonyl-N-methyl-(3-benzyloxy-2-chloro-4-methoxy)-phenylalanine 
• 220903-43-5 (R)-N-tert-butyloxycarbonyl-(3-benzyloxy-2-chloro-4-methoxy)-phenylalanine 
• 621-59-0 isovanillin 
• 220903-46-8 N-tert-butyloxycarbonyl-N-methyl-(3-benzyloxy-2-chloro-4-methoxy)-(R)-phenylalanyl-N-methyl-(S)-phenylalanine allyl ester 
• 53713-77-2 3-benzyloxy-2-chloro-4-methoxy-benzaldehyde 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 
• 210105-82-1 3-benzyloxy-2-chloro-4-methoxybenzyl bromide 
• 110038-82-9 3-benzyloxy-2-chloro-4-methoxybenzyl alcohol 

Downstream Products

• 210105-89-8 N-benzyloxycarbonyl-(O-benzyloxycarbonyl)-(R)-tyrosyl-N-methyl-(3-benzyloxy-2-chloro-4-methoxy)-(R)-phenylalanyl-N-methyl-(S)-phenylalanine allyl ester 
• 210105-91-2 N-benzyloxycarbonyl-(O-benzyloxycarbonyl)-(R)-tyrosyl-N-methyl-(3-benzyloxy-2-chloro-4-methoxy)-(R)-phenylalanyl-N-methyl-(S)-phenylalanine-(R)-(piperazine-2,5-dione)methyl ester 
• 210105-94-5 N-benzyloxycarbonyl-(O-benzyloxycarbonyl)-(R)-tyrosyl-N-methyl-(3-benzyloxy-2-chloro-4-methoxy)-(R)-phenylalanyl-N-methyl-(S)-phenylalanine 
• 147317-36-0 epi-pepticinnamin E 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of the Ras farnesyltransferase inhibitor pepticinnamin E

A modularly built bisubstrate inhibitor, the natural product pepticinnamin E (shown on the right) was synthesized for the first time. In the case of in vitro assays it inhibits the enzyme farnesyltransferase with respect to both the peptide substrate and farnesylpyrophosohate (K1 = 30 and 8 μM, respectively). The inhibitory activity is decisively influenced by the central tripeptide unit and the absolute configuration of the non-proteinogenic amino acid incorporated therein.