53713-77-2Relevant articles and documents
Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof
-
, (2022/01/04)
Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as amyotrophic lateral sclerosis. These compounds and pharmaceutical compositions are also useful as antivirals and antimicrobial agents.
Synthesis and in vitro evaluation of the Ras farnesyltransferase inhibitor pepticinnamin E
Hinterding, Klaus,Hagenbuch, Patrizia,Retey, Janos,Waldmann, Herbert
, p. 1236 - 1239 (2007/10/03)
A modularly built bisubstrate inhibitor, the natural product pepticinnamin E (shown on the right) was synthesized for the first time. In the case of in vitro assays it inhibits the enzyme farnesyltransferase with respect to both the peptide substrate and farnesylpyrophosohate (K1 = 30 and 8 μM, respectively). The inhibitory activity is decisively influenced by the central tripeptide unit and the absolute configuration of the non-proteinogenic amino acid incorporated therein.
Method for improving the absorption and effectiveness of a catecholamine compound
-
, (2008/06/13)
A catecholamine compound is converted to a new mono O-phosphate ester derivative thereof which exhibit improved absorption and effectiveness.