757189-07-4Relevant articles and documents
Synthesis of novel pyrazolopyrrolizinones as prospective anticancer agents
Rochais, Christophe,Sopkova-de Oliveira Santos, Jana,Dallemagne, Patrick,Rault, Sylvain
, p. 2063 - 2077 (2008/01/27)
Herein we describe the access of novel pyrazolopyrrolizinones from commercial arylacetonitriles. The first step conducts to the corresponding aminoester which was first submitted to Clauson-Kaas procedure. Amidification and cyclisation afford then the fir
First synthesis of arylpyrrolo- and pyrazolopyrrolizinones as useful agents with potential biological interest
Rochais, Christophe,Lisowski, Vincent,Dallemagne, Patrick,Rault, Sylvain
, p. 6353 - 6355 (2007/10/03)
Novel arylpyrrolo- and pyrazolopyrrolizinones were prepared in three or four steps starting from aminoarylpyrrole and pyrazole carboxylates through the cyclisation of a Vilsmeier-Haack intermediate. This synthesis was enhanced by diverse N-protections of