757189-07-4

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 91857-59-9 ethyl 4-amino-5-(4-chlorophenyl)-2H-pyrazole-3-carboxylate 

Downstream Products

• 757188-96-8 3-(4-chlorophenyl)-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole 

Relevant academic research and scientific papers

Synthesis of novel pyrazolopyrrolizinones as prospective anticancer agents

Herein we describe the access of novel pyrazolopyrrolizinones from commercial arylacetonitriles. The first step conducts to the corresponding aminoester which was first submitted to Clauson-Kaas procedure. Amidification and cyclisation afford then the fir

First synthesis of arylpyrrolo- and pyrazolopyrrolizinones as useful agents with potential biological interest

Novel arylpyrrolo- and pyrazolopyrrolizinones were prepared in three or four steps starting from aminoarylpyrrole and pyrazole carboxylates through the cyclisation of a Vilsmeier-Haack intermediate. This synthesis was enhanced by diverse N-protections of