91857-59-9Relevant academic research and scientific papers
Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin-dependent kinases (CDKs) inhibitory activities
Geffken, Detlef,Soliman, Raafat,Soliman, Farid S.D.,Abdel-Khalek, Magdi M.,Issa, Doaa A.E.
, p. 408 - 420 (2012/04/04)
Two series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4- ones were designed, synthesised, and evaluated for their antibacterial activities and CDKs inhibitory activities. The pyridazine derivative: 6-phenyl-5-phenylhydrazono-2,3,4,5-tetrahydropyridazine- 3,4-dione (3a) revealed activity against Staphylococcus aureus as Gram-positive bacteria while compound 2-(2- Ethoxyphenyl-5-Phenylpiperazinosulfonamido)-3H-pyrido [2,3-d]pyrimidin-4-one (13c) was showing moderate antifungal activity against Candida albicans.
Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivatives as potential anti-cancer agents
Devegowda, Vani N.,Kim, Jung Hyun,Han, Ki-Cheol,Yang, Eun Gyeong,Choo, Hyunah,Pae, Ae Nim,Nam, Ghilsoo,Choi, Kyung Il
scheme or table, p. 1630 - 1633 (2010/06/19)
A novel series of 3,5,6-trisubstituted pyrazolo[4,3-d]pyrimidin-7-one derivatives, especially 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-ones were synthesized and evaluated for their in vitro anticancer activities against various human cancer cell line
Synthesis of novel pyrazolopyrrolizinones as prospective anticancer agents
Rochais, Christophe,Sopkova-de Oliveira Santos, Jana,Dallemagne, Patrick,Rault, Sylvain
, p. 2063 - 2077 (2008/01/27)
Herein we describe the access of novel pyrazolopyrrolizinones from commercial arylacetonitriles. The first step conducts to the corresponding aminoester which was first submitted to Clauson-Kaas procedure. Amidification and cyclisation afford then the fir
