757195-59-8Relevant academic research and scientific papers
Enantioselective synthesis of (+)-l-733,060
Cherian, Shijo K.,Kumar, Pradeep
, p. 982 - 987 (2008/02/03)
An efficient enantioselective synthesis of (+)-l-733,060 from cinnamyl alcohol is described. The key steps include a Sharpless asymmetric epoxidation, a regioselective allyl opening of an epoxide and piperidine ring formation via a one pot Staudinger/aza-Wittig reaction.
Allylation of aldehydes and imines: Promoted by reuseable polymer-supported sulfonamide of N-glycine
Li, Gui-Long,Zhao, Gang
, p. 633 - 636 (2007/10/03)
A allylation of aldehydes and imines (generated in situ from aldehydes and amines) with allyltributyltin promoted by recoverable and reusable the polymer-supported sulfonamide of N-glycine has been developed. Good to high yields were obtained in various cases. Most of the SnBu3 residue can be recovered as Bu3SnCl. Highly stereoselective synthesis of N-Boc-(2S,3S)-3-hydroxy-2-phenylpiperidine 7 was achieved by using the P4a-mediated allylation of Boc-L-phenylglycinal as a key step.
Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721
Yamazaki, Naoki,Atobe, Masakazu,Kibayashi, Chihiro
, p. 7979 - 7982 (2007/10/03)
An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of
