757203-27-3 Usage
General Description
2,2-Difluoro-2-(fluorosulfonyl)acetic acid triethylsilyl ester is a chemical compound with the molecular formula C10H19F3O4SSi. It is an organofluorine compound that is commonly used in organic synthesis as a reagent for introducing the difluoromethyl group into various organic molecules. 2,2-Difluoro-2-(fluorosulfonyl)acetic acid triethylsilyl ester is often utilized in the pharmaceutical industry for the production of drug candidates and has potential applications in agrochemicals and materials science. It is a valuable building block in chemical synthesis due to its unique fluorinated structure, and its triethylsilyl ester derivative makes it more stable and easier to handle in laboratory settings.
Check Digit Verification of cas no
The CAS Registry Mumber 757203-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,7,2,0 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 757203-27:
(8*7)+(7*5)+(6*7)+(5*2)+(4*0)+(3*3)+(2*2)+(1*7)=163
163 % 10 = 3
So 757203-27-3 is a valid CAS Registry Number.
757203-27-3Relevant articles and documents
Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA): A new, highly efficient difluorocarbene reagent
Dolbier Jr., William R.,Tian, Feng,Duan, Jian-Xin,Li, An-Rong,Ait-Mohand, Samia,Bautista, Olivia,Buathong, Saiwan,Baker, J. Marshall,Crawford, Jen,Anselme, Pauline,Cai, Xiao Hong,Modzelewska, Aneta,Koroniak, Henryk,Battiste, Merle A.,Chen, Qing-Yun
, p. 459 - 469 (2004)
TFDA is readily prepared from the reaction of fluorosulfonyldifluoroacetic acid with trimethylsilyl chloride, and it is a very effective and efficient source of difluorocarbene for use in addition reactions to alkenes of a broad scope of reactivities. Acid-sensitive substrates may require an additional purification step involving treatment of the distilled TFDA with sufficient Et3N to remove the acid impurity. Other trialkylsilyl fluorosulfonyldifluoroacetates can also be prepared, and they have been found to have reactivities similar to TFDA. The triethyl derivative, TEFDA is more convenient to prepare in a pure state and has similar reactivity to TFDA. Thus, it may prove to be a superior reagent.
