75732-48-8

Usage

Class of compounds

Hemiacetals

Formation

Formed by the reaction of an aldehyde or ketone with an alcohol

Use in organic synthesis

Acts as a protecting group for alcohols and thiols, temporarily blocking their reactivity in chemical reactions

Potential applications

Medicinal chemistry, drug synthesis, and the production of various other organic compounds.

Upstream product

• 1120-71-4 1,3-propanesultone 
• 67-64-1 acetone 

Relevant academic research and scientific papers

Methods and compositions for treating amyloid-related diseases

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

Lithium aluminum hydride-aluminum hydride reduction of sultones

Lithium aluminum hydride-aluminum hydride reduction of secondary and tertiary (C-O) substituted γ-sultones or α-alkyl-β'-hydroxy γ-sultones yields mercapto alcohols and mercapto diols, respectively, in fair to good yield.These products result from S-O cleavage of the sultone ring.Primary sultones and α-dialkyl-β'-hydroxy γ-sultones give predominantly C-O cleavage to form sulfonic acid derivatives. β-Sultones are much less reactive toward the mixed hydride, and refluxing in dioxane is required for their reduction.