75736-53-7 Usage
Description
HEXADECANOIC-16,16,16-D3 ACID, also known as Palmitic Acid-d3, is an isotope-labeled analog of Palmitic Acid, a common fatty acid found in plants and animals. It is the first fatty acid produced during fatty acid synthesis and serves as a precursor for longer fatty acids. The body converts excess carbohydrates into Palmitic Acid, making it an essential component in lipid metabolism.
Uses
Used in Pharmaceutical Industry:
HEXADECANOIC-16,16,16-D3 ACID is used as a pharmaceutical agent for studying lipid metabolism and its role in various diseases. As an isotope-labeled analog, it allows researchers to track and analyze the metabolic pathways and mechanisms involving Palmitic Acid, providing valuable insights into the development of therapeutic strategies for metabolic disorders and other related conditions.
Used in Research Applications:
HEXADECANOIC-16,16,16-D3 ACID is used as a research tool for investigating the synthesis, metabolism, and regulation of fatty acids in biological systems. Its isotope labeling enables the differentiation between endogenous and exogenous Palmitic Acid, facilitating the study of lipid metabolism and its impact on cellular processes and disease progression.
Used in Nutritional Studies:
HEXADECANOIC-16,16,16-D3 ACID is used as a tracer in nutritional studies to assess the bioavailability and metabolism of fatty acids in the human body. By tracking the labeled Palmitic Acid, researchers can gain a better understanding of how dietary fats are absorbed, utilized, and metabolized, ultimately contributing to the development of healthier dietary guidelines and interventions.
Used in Drug Development:
HEXADECANOIC-16,16,16-D3 ACID is used as a potential drug candidate in the development of therapies targeting lipid metabolism-related disorders. Its unique properties as an isotope-labeled analog allow for the exploration of its therapeutic potential in modulating lipid synthesis, storage, and utilization, offering new avenues for the treatment of metabolic diseases and other conditions influenced by lipid metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 75736-53-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,7,3 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 75736-53:
(7*7)+(6*5)+(5*7)+(4*3)+(3*6)+(2*5)+(1*3)=157
157 % 10 = 7
So 75736-53-7 is a valid CAS Registry Number.
75736-53-7Relevant articles and documents
Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling
Wepy, James A.,Galligan, James J.,Kingsley, Philip J.,Xu, Shu,Goodman, Michael C.,Tallman, Keri A.,Rouzer, Carol A.,Marnett, Lawrence J.
, p. 360 - 374 (2019/02/19)
Abstract Lysophospholipids (LysoPLs) are bioactive lipid species involved in cellular signaling processes and the regulation of cell membrane structure. LysoPLs are metabolized through the action of lysophospholipases, including lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2). A new X-ray crystal structure of LYPLA2 compared with a previously published structure of LYPLA1 demonstrated near-identical folding of the two enzymes; however, LYPLA1 and LYPLA2 have displayed distinct substrate specificities in recombinant enzyme assays. To determine how these in vitro substrate preferences translate into a relevant cellular setting and better understand the enzymes’ role in LysoPL metabolism, CRISPR-Cas9 technology was utilized to generate stable KOs of Lypla1 and/or Lypla2 in Neuro2a cells. Using these cellular models in combination with a targeted lipidomics approach, LysoPL levels were quantified and compared between cell lines to determine the effect of losing lysophospholipase activity on lipid metabolism. This work suggests that LYPLA1 and LYPLA2 are each able to account for the loss of the other to maintain lipid homeostasis in cells; however, when both are deleted, LysoPL levels are dramatically increased, causing phenotypic and morphological changes to the cells.—Wepy, J. A., James J. Galligan, P. J. Kingsley, S. Xu, M. C. Goodman, K. A. Tallman, C. A. Rouzer, and L. J. Marnett. Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.
