75736-52-6Relevant academic research and scientific papers
NUCLEOSIDE PRODRUGS AND USES RELATED THERETO
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, (2021/02/26)
Disclosed are acyclic nucleoside prodrugs with improved metabolic stability and oral bioavailability. In general, the prodrugs are derivatives of acyclic nucleoside phosphonates containing a lipid-like moiety that can increase oral absorption and subsequent stability in the liver and plasma. Preferably, the lipid-like moiety can resist enzyme-mediated ω-oxidation, such as ω -oxidation catalyzed by cytochrome P450 enzymes. Also disclosed are pharmaceutical formulations of the acyclic nucleoside prodrugs. The acyclic nucleoside prodrugs and pharmaceutical formulations thereof can be used to treat viral infections, such as HIV infections, and/or viral-associated cancer, such as HPV-associated cancers.
An efficient and convenient synthesis of deuterium-labelled seminolipid isotopomers and their ESI-MS characterization
Franchini, Laura,Panza, Luigi,Kongmanas, Kessiri,Tanphaichitr, Nongnuj,Faull, Kym F.,Ronchetti, Fiamma
, p. 78 - 85 (2008/09/20)
Seminolipids 1a and 1b and galactosylalkylacylglycerols 2a and 2b, labelled with deuterium on the alkyl or acyl chain, respectively, were obtained isotopically and chemically pure through a straightforward synthesis from protected glycidyl galactoside 3 i
Investigation of surfactant conformation and order at the liquid-liquid interface by total internal reflection sum-frequency vibrational spectroscopy
Conboy, John C.,Messmer, Marie C.,Richmond, Geraldine L.
, p. 7617 - 7622 (2007/10/03)
The conformational order of sodium dodecyl sulfate (SDS) adsorbed at the D2O-CCl4 interface has been examined by total internal reflection sum-frequency vibrational spectroscopy. A change in conformation of the alkyl chain with increased surface coverage at the liquid-liquid interface is observed. A series of aqueous surfactant concentrations have been examined in order to determine the effect of surface coverage on the conformation of the alkyl chains at the interface. Polarization studies indicate that, for the concentration range examined, the symmetry axis of the terminal methyl group on the alkyl chain is oriented primarily along the surface normal. Identification of spectral features in the C-H region of the infrared region is facilitated by examination of the sum-frequency spectrum from an analogous deuterated compound.
