75737-01-8

Upstream product

• 502-49-8 cycloactanone 
• 100-52-7 benzaldehyde 
• 17356-08-0 thiourea 
• 69202-72-8 2-benzylidene-cyclooctanone 

Downstream Products

• 75737-11-0 4-Phenyl-2-[1-phenyl-meth-(E)-ylidene]-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one 
• 75737-13-2 2-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-4-phenyl-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one 
• 75737-27-8 4-Phenyl-2-(p-tolyl-hydrazono)-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one 
• 75737-26-7 4-Phenyl-2-(phenyl-hydrazono)-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one 
• 75737-12-1 4-Phenyl-2-[1-p-tolyl-meth-(E)-ylidene]-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one 
• 75737-06-3 2-Acetyl-4-phenyl-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one 

Relevant academic research and scientific papers

Highly chemoselective multicomponent biginelli-type condensations of cycloalkanones, urea or thiourea and aldehydes

The classical Biginelli reaction is considerably extended by use of cycloalkanones instead of 1,3-dicarbonyl compounds. Use of TMSCl as a Lewis acid allowed one-pot chemoselective multicomponent Biginelli reactions between cycloalkanones, urea or thiourea, and aldehydes. Under similar reaction conditions, thiourea exhibited different behavior to urea, and aliphatic aldehydes showed lower reactivity than aromatic aldehydes. A possible mechanism to account for the reaction is proposed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

Reactions with (Arylmethylene)cycloalkanones. 4. Synthesis of Derivatives of Octahydrocyclooctathiazolopyrimidin-3-one of Expected Biological Activity

Cyclooctapyrimidin-2-thiones (III) were prepared by heating 2-(arylmethylene)cyclooctanones with thiourea in ethanolic potassium hydroxide.Compounds III reacted with chloroacetic acid to yield 2-acetyl-2,3,6,7,8,9,10,11-octahydro-5H-cyclooctathiazolopyrimidin-3-ones (IV).The 2-arylmethylene derivatives (V) and the 2-arylhydrazono derivatives VI were prepared.