75745-30-1

Upstream product

• 14500-40-4 2-bromo-2-phenyl-1-(p-tolyl)ethanone 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 75745-08-3 2-thienylidene-2-amino-4-p-tolyl-5-phenylthiazole 
• 75745-04-9 (5-bromo-2-thienylidene)-2-amino-4-p-tolyl-5-phenylthiazole 
• 75745-12-9 4-(5-Bromo-thiophen-2-yl)-3-chloro-1-(5-phenyl-4-p-tolyl-thiazol-2-yl)-azetidin-2-one 
• 75745-19-6 2'-(5-Bromo-thiophen-2-yl)-5-phenyl-4-p-tolyl-[2,3']bithiazolyl-4'-one 
• 75758-28-0 3-Chloro-1-(5-phenyl-4-p-tolyl-thiazol-2-yl)-4-thiophen-2-yl-azetidin-2-one 
• 75745-25-4 2-thienyl-3-<2-(4-tolyl-5-phenyl)thiazolyl>thiazolidin-4-one 

Relevant academic research and scientific papers

One pot synthesis using supported reagents system KSCN/SiO 2-RNH3OAc/Al2O3: Synthesis of 2-aminothiazoles and N-allylthioureas

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from commercially available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH 3OAc/Al2O3, in which α-halo ketone reacts first KSCN/SiO2 and the product, α-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazoles, in good yield and allyl bromide reacts with KSCN/SiO 2 and the product, allyl isothiocyanate, reacts with RNH 3OAc/Al2O3 to give N-allylthiourea.

One-pot synthesis of 2-aminothiazoles using supported reagents

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles from α-bromo ketones in one-pot using a supported reagents system, KSCN/SiO2-RNH3OAc/Al2O3, in which α-bromo ketone reacts first with KSCN/SiO2 and the product, α-thiocyano ketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazole, in high yield.