7579-74-0Relevant academic research and scientific papers
Synchronous Ar-F and Ar-Sn bond formation through fluorostannylation of arynes
Yoshida, Hiroto,Yoshida, Ryuma,Takaki, Ken
, p. 8629 - 8632 (2013)
An aryne insertion into the F-Sn bond of tributyltin fluoride leads to the synchronous formation of Ar-F and Ar-Sn bonds to afford diverse 2-fluoroarylstannanes straightforwardly. The formal total synthesis of flurbiprofen by using a fluorostannylation product is also reported. Copyright
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 001223; 001224, (2015/09/28)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
A Sn atom-economical approach toward arylstannanes: Ni-catalysed stannylation of aryl halides using Bu3SnOMe
Komeyama, Kimihiro,Asakura, Ryota,Takaki, Ken
supporting information, p. 8713 - 8716 (2015/08/24)
Stannylation of carbon-halogen bonds is one of the most promising and straightforward approaches for the preparation of organostannane compounds. Although a wide variety of methods are now available, all protocols require the use of highly nucleophilic organometals or wasteful stannyl sources like distannanes. Here, we report a new nickel-catalysed stannylation of aryl and alkenyl-halides using Bu3SnOMe as a stannyl source to afford aryl and vinyl-stannanes, respectively. This method enables the stannylation of not only bromides, but also chlorides and triflates to furnish functionalized aryl- and alkenyl-stannanes without the release of wasteful and toxic stannyl byproducts.
Convenient syntheses of aryl and perfluoroaryl trichlorogermanes and germatranes via an organotin route
Kultyshev, Roman G.,Prakash, G.K. Surya,Olah, George A.,Faller, Jack W.,Parr, Jonathan
, p. 3184 - 3188 (2008/10/09)
Aryl- and (perfluoroaryl)trichlorogermanes ArGeCl3(Ar = C 6H5, 2-FC6H4, 3,5-(CF 3)2C6H3, C6F5, 2,3,5,6-F4C5N) are easily obtained in 60-80% yields from the corresponding tributyl-stannanes and GeCl4 (1:1) at 150 °C in the absence of a solvent. Although the tin-to-germanium transmetalation of C6F5 group is sluggish, it is facilitated by addition of 1-2 mol % AIBN (2,2′-azobis(isobutyronitrile)).
Thiostannylation of arynes with stannyl sulfides: Synthesis and reaction of 2-(arylthio)arylstannanes
Yoshida, Hiroto,Terayama, Tsuguaki,Ohshita, Joji,Kunai, Atsutaka
, p. 1980 - 1981 (2008/10/09)
Arynes were found to insert into a sulfur-tin σ-bond of stannyl sulfides to give a variety of 2-(arylthio)arylstannanes, whose carbon-tin bonds were applicable to further transformations.
