757962-04-2

Upstream product

• 757961-95-8 (4-methoxy-3-nitro-phenyl)-(3,4-dimethoxy-phenyl)-methanol 
• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 

Downstream Products

• 757962-05-3 (5-methoxy-2-nitrophenyl)(3,4,5-trimethoxyphenyl)methanone 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of combretabenzodiazepines: A novel class of anti-tubulin agents

In the present manuscript, starting from the 1,4-benzodiazepin-2-one nucleus, a privileged structure in medicinal chemistry, we have synthesized a novel class of cis-locked combretastatins named combreatabenzodiazepines. They show similar cytotoxic and antitubulin activity compared to combretastatin A-4 in neuroblastoma cells, showing a better pharmacokinetic profile. This class of compounds has therefore the potential for further development as antitubulin agents.

Diphenylethylene compounds and uses thereof

The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents

A new type of inhibitor of tubulin polymerization was discovered on the basis of the combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7, strongly inhibited tubulin polymerization in vitro and significantly arrested cel