757967-75-2Relevant academic research and scientific papers
Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells
Miyazaki, Anna,Yokoi, Toshio,Tachibana, Yoshifumi,Enomoto, Riyo,Lee, Eibai,Bokonyi, Gyongyi,Keri, Gyorgy,Tsuda, Yuko,Okada, Yoshio
, p. 6323 - 6327 (2004)
It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp- Lys-Cys)-Thr-NH2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.
