757994-54-0

Basic information

• Product Name: (S)-2,3,4,5,2',5'-Hexahydro-[1,3']bipyrrolyl-1',5'-dicarboxylic acid 1'-benzyl ester 5'-methyl ester
• Synonyms: (S)-2,3,4,5,2',5'-Hexahydro-[1,3']bipyrrolyl-1',5'-dicarboxylic acid 1'-benzyl ester 5'-methyl ester
• CAS NO: 757994-54-0
• Molecular Weight: 330.384
• Mol File: 757994-54-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-2,3,4,5,2',5'-Hexahydro-[1,3']bipyrrolyl-1',5'-dicarboxylic acid 1'-benzyl ester 5'-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2,3,4,5,2',5'-Hexahydro-[1,3']bipyrrolyl-1',5'-dicarboxylic acid 1'-benzyl ester 5'-methyl ester(757994-54-0)
• EPA Substance Registry System: (S)-2,3,4,5,2',5'-Hexahydro-[1,3']bipyrrolyl-1',5'-dicarboxylic acid 1'-benzyl ester 5'-methyl ester(757994-54-0)

Safety Data

• Hazardous Substances Data: 757994-54-0(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 16217-15-5 1-benzyloxycarbonyl-4-oxo-L-proline methyl ester 

Downstream Products

• 394735-50-3 C₁₈H₂₁NO₅ 
• 757994-70-0 N-benzyloxycarbonyl-3-(2-methylallyl)-4-oxo-L-proline methyl ester 
• 757994-56-2 N-(benzyloxycarbonyl)-3-(3-methylbuten-2-yl)-4-oxo-L-proline methyl ester 
• 757994-62-0 (2S,3R,4S)-4-Hydroxy-3-(3-methyl-but-2-enyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 394735-53-6 (2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant articles and documents

NOVEL COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

CYCLOBUTENEDIONE GROUPS-CONTAINING COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

Carboxy mediated stereoselective reduction of ketones with sodium triacetoxyborohydride: Synthesis of novel 3,4-fused tetrahydropyran and tetrahydrofuran prolines

In the presence of a carboxyl group positioned for participation, NaBH(OAc)3 will reduce the usually unreactive ketones in a stereoselective manner. This reaction was applied in a key step to prepare precursors 7 and 15 toward the title compounds 1 and 2. These results are consistent with the exchange of one of the acetoxy groups in the reducing agent with the carboxy group followed by intramolecular delivery of the hydride.