758-10-1Relevant articles and documents
Thioglycine and l-thiovaline: Biologically active H2S-donors
Zhou, Zongmin,Von Wantoch Rekowski, Margarete,Coletta, Ciro,Szabo, Csaba,Bucci, Mariarosaria,Cirino, Giuseppe,Topouzis, Stavros,Papapetropoulos, Andreas,Giannis, Athanassios
scheme or table, p. 2675 - 2678 (2012/05/31)
Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H2S donors hold promise as novel treatments for cardiovascular diseases.
