75810-50-3Relevant academic research and scientific papers
Toward lead-oriented synthesis: One-pot version of castagnoli condensation with nonactivated alicyclic anhydrides
Ryabukhin, Sergey V.,Panov, Dmitriy M.,Granat, Dmitry S.,Ostapchuk, Eugeniy N.,Kryvoruchko, Dmitriy V.,Grygorenko, Oleksandr O.
, p. 146 - 153 (2014/04/03)
One-pot variation of Castagnoli condensation, that is, reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids, as well as their benzo-analogues. Utility of the method to multigram preparation of building blocks and synthetic intermediates was also demonstrated. The final products are obtained in high yields and diastereoselectivity. The method fits well in the concept of lead-oriented synthesis; in particular, it can be used for the design of lead-like compound libraries, even if the strictest cut-offs are applied to the physicochemical properties of their members.
Piperidine and pyrrolidine alcohols
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, (2008/06/13)
This disclosure describes novel compounds of the formula: STR1 where A is --CH2 OH or STR2 wherein R4 and R5 each independently represent hydrogen or lower alkyl having 1 to 2 carbon atoms or together with N represent STR3 and, R1 is hydrogen or lower alkyl having 1 to 2 carbon atoms, and R2 and R3 each independently represent hydrogen, chloro, fluoro, methyl, methoxy or together, represent methylenedioxy, and n is 1 or 2, provided that one of R2 and R3 is other than hydrogen which are useful as hypolipidemic agents.
