75814-89-0Relevant academic research and scientific papers
Conformational requirements for histamine H2-receptor inhibitors: A structure-activity study of phenylene analogues related to cimetidine and tiotidine
Hoffman,Pietruszkiewicz,Habecker,Phillips,Bolhofer,Cragoe Jr.,Torchiana,Lumma Jr.,Baldwin
, p. 140 - 144 (2007/10/02)
Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H2 receptors. The flexible methylthioethyl connecting chain was repl
