75816-32-9Relevant academic research and scientific papers
Synthesis of 5- and 7-Bromotryptophan and of 9>-β-corticotrophin-(1-24)-tetracosapeptide, a Highly Potent Corticotrophin Analogue
Allen, Mark C.,Brundish, Derek E.,Wade, Roy
, p. 1928 - 1932 (2007/10/02)
The synthesis of 5- and 7-bromo-L-tryptophans via Fischer cyclisation of the appropriate bromophenylhydrazone of 4-acetamido-4,4-bis(ethoxycarbonyl)butanal is described.The title tetracosapeptide was synthesised using standard methods of stepwise and fragment condensation.The product was pure as judged by amino-acid analysis after acidic or enzymic hydrolysis and by high pressure liquid chromatography.In an isolated adrenal cell bioassay, the peptide had a steroidogenic potency 2.4 times that of Synacthen.
