75837-23-9Relevant academic research and scientific papers
Simple and efficient synthesis of tetrahydro-β-carbolines via the Pictet-Spengler reaction in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)
Wang, Li-Na,Shen, Su-Li,Qu, Jin
, p. 30733 - 30741 (2014/08/05)
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) can act as both the solvent and the catalyst to promote the Pictet-Spengler reactions between tryptamine derivatives and aldehydes or activated ketones. For most substrates, removing the low boiling point HFIP by distillation directly afforded tetrahydro-β-carbolines in high yields.
Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
-
, (2008/06/13)
PCT No. PCT/EP97/01582 Sec. 371 Date Nov. 12, 1998 Sec. 102(e) Date Nov. 12, 1998 PCT Filed Mar. 27, 1997 PCT Pub. No. WO97/37658 PCT Pub. Date Oct. 16, 1997The present invention concerns the use of beta-carboline derivatives of formula I bearing at least a free or esterified carboxylic group on the piperidine ring, for the preparation of pharmaceutical compositions having antimetastatic properties.
INTRAMOLECULAR CYCLOADDITION OF AN INDOLENINE
Hajicek, Josef,Trojanek, Jan
, p. 1823 - 1826 (2007/10/02)
Attempted transformation of readily accessible 18-methylenevincadifformine (I) to indolenine VI in acidic medium afforded unexpectedly the intramolecular cycloadduct VIII in almost quantitative yield
