75844-28-9

Usage

Uses

Used in Pharmaceutical Research and Development:
6-AMINO-5-METHYLINDOLE is used as a key building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties contribute to the development of new drugs, enhancing the range of therapeutic options available.
Used in Chemical Research:
In the field of chemical research, 6-AMINO-5-METHYLINDOLE serves as an important compound for studying the properties and reactions of indole derivatives. This helps in advancing the understanding of chemical processes and the creation of novel chemical entities.
It is crucial to handle 6-AMINO-5-METHYLINDOLE with care due to its potential health hazards if not managed properly, ensuring safety in research and pharmaceutical applications.

Upstream product

• 72521-00-7 5-methyl-6-nitro-1⁽²⁾H-indazole 
• 72521-00-7 5-methyl-6-nitro-1H-indazole 
• 2124-47-2 5-nitro-2,4-dimethylaniline 
• 95-68-1 2,4-Xylidine 

Downstream Products

• 71785-46-1 1,6-Dihydro-5H-pyrazolo<4,3-g>chinazolin-5-on 
• 73908-01-7 pyrazolo<4,3-g>quinazoline-5,7-dione 
• 78416-49-6 7-Amino-1,6-dihydro-5H-pyrazolo<4,3-g>chinazolin-5-on 

Relevant academic research and scientific papers

Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity

The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented,

BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS

The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

Lin-benzoaminopurinols

Novel benzologs or pyrazolo-quinazoline derivatives of the formula (I) STR1 wherein X and Y are independently selected from oxygen, sulphur and imino and wherein ring (C) is a pyrazole ring fused to ring (B) via one of the three ortho positions or sides of ring (B); the fused pyrazole ring (C) is either in the 4,3- or the 3,4-arrangement; and tautomers of formula (I) compounds; when X is not oxygen, i.e. stands for sulphur or imino, Y may stand for a covalent bond that links the hydrogen directly to the carbon atom in position 2. Two methods for producing the novel formula (I) compounds are disclosed. The first or indazole method starts from a precursor having a benzene moiety (ring B) and a pyrazolo moiety (ring C) fused therewith, i.e. the indazole structure; ring (B) carries two vicinal substituents for forming the pyrimidine moiety or ring (A) by cyclization. The second or quinazoline method starts from a precursor having the pyrimidine moiety (A) and the benzene moiety (B) fused therewith, i.e. the quinazoline structure, and carrying two vicinal substituents for forming the pyrazole moiety (C) by cyclization. The first method, in addition to yielding the novel benzologs, provides for improved synthesis of previously disclosed benzo-allopurinols. Novel compounds of formula (I) are benzologs of such well known and biologically active compounds as oxipurinol, aminopurinol and thiopurinol and are expected to be applicable for comparable pharmaceutical purposes.