75854-93-2Relevant academic research and scientific papers
Aerobic double dehydrogenative cross coupling between cyclic saturated ketones and simple arenes
Gigant, Nicolas,Baeckvall, Jan-E.
supporting information, p. 5890 - 5894 (2014/05/20)
The synthesis of 3-aryl-2-cyclohexenones is a topic of current interest as they are not only privileged structures in bioactive molecules, but they are also relevant feedstocks for the synthesis of substituted phenols or anilines, which are ubiquitous structural elements both in drug design and medicinal chemistry. A simple and sustainable one-pot aerobic double dehydrogenative reaction under mild conditions for the introduction of arenes in the β-position of cyclic ketones has been developed. Starting from the corresponding saturated ketone, this reaction sequence proceeds under relatively low Pd catalyst loading and involves catalytic amounts of electron-transfer mediators (ETMs) under ambient oxygen pressure. A simple and sustainable one-pot aerobic double dehydrogenative reaction under mild conditions for the introduction of arenes in the β-position of cyclic ketones has been developed (see scheme). Starting from the corresponding saturated ketone, this reaction sequence proceeds under relatively low Pd catalyst loading and involves catalytic amounts of electron-transfer mediators (ETMs) under ambient oxygen pressure.
Diprotonation de derives phenoliques. Nouvelle synthese d'aryl-4 et d'aryl-3 cyclohexenones et de benzobicycloheptanes.
Jacquesy, Jean-Claude,Jouannetaud, Marie-Paule
, p. 295 - 303 (2007/10/02)
In SbF5-HF paracresol and its methyl ether are diprotonated and react with monosubstituted benzenes (chlorobenzene, toluene, acetanilide) to give as primary products and after hydrolysis 4-aryl cyclohexenones 4, 7, 9.The higher the acidity, the faster is
